urinary
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Specimens- voided urine: dirty catch has squams
- catheterized urine: tip scraping causes papillary groups, pooled specimen causes degeneration
- bladder washing
- upper tract washing
- upper tract brushing
- ileal conduit: degenerated epithelial cells
Adequacy- adequate
- unsatisfactory
- vaginal cells only
- obscuring inflammation or lubricant
- blood only
- marked degenerative change
Negative for high-grade malignancy- Normal
- urothelium
- umbrella cells
- multinucleated
- degeneration artifacts
- nuclear atypia
- Melamed-Wolinska bodies
- intermediate cells
- basal cells (washings, catheterized urine)
- cell clusters (washings, catheterized urine)
- squamous cells
- seminal vesicle cells (rare)
- ileal conduit
- intestinal cells
- degenerate changes
- Non-neoplastic
- UTI
- crystals
- Phosphate: coffin lid prisms
- Ammonium biurate: thorn apples
- Uric acid: varying shape
- Calcium oxalate: oval, dumbbell, small octahedral
- Bilirubin: brown granules and needles
- Cholesterol
- Cystine: hexagonal plates
- Leucine: spheres with radiation striations
- Tyrosine: needles
- casts
- hyaline: normal
- granular: normal
- RBC cast: glomerular disease
- WBC cast: tubulointerstitial disease, transplant rejection
- epithelial cast: ATN
- waxy cast
- fatty cast: nephrotic syndrome
- reactive
- benign stone atypia
- treatment effect
- decoy cells
- Melamed Wolinska bodies (degenerating urothelial cells)
- corpora amylacea
- rare atypical cells
- Papillary groups
Atypical- avoid this category if possible
- rare small highly atypical cells
- degenerated atypical cells with intact nuclear outlines
- coy cells (irregular nuclear membrane)
High grade malignancy
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