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thyroid
hyalinizing trabecular tumor
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Histology
trabecular, insular
large, elongated cells
intracytoplasmic bodies
nucleus
oval
nuclear grooves
pseudoinclusions
perinuclear halo
Stains
TTF1+
thyroglobulin+
Ddx
papillary carcinoma
similar nuclear features
more invasive
follicular adenoma
lack nuclear features
paraganglioma
chromogranin, synaptophysin positive
TTF1, thyroglobulin negative
medullary carcinoma
amyloid present
thyroglobulin negative
Associations
RET/PTC gene rearrangements