papillary carcinoma


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  • Clinical

    • 80% of thyroid cancer
    • female predominance (4:1)
    • radiation exposure
    • worse prognosis if male, age over 45
    • half will have regional node metastasis

  • Histology

    • papillary (fibrovascular cores)
    • nuclear
      • nuclear pseudoinclusions
      • nuclear grooves
      • overlapping nuclei
    • cytoplasmic pseudoinclusions
    • psammoma bodies
    • variants
      • cystic in nodes
      • microcarcinoma
      • follicular variant
      • diffuse sclerosing variant
      • oncocytic variant
      • tall columnar cell variant

  • Ddx

  • Associations

    • BRAF point mutation
    • RET/PTC rearrangements
    • N-ras
    • TRK rearrangements
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