clear cell adenocarcinoma


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  • Names

    • clear cell adenocarcinoma
    • mesonephric carcinoma

  • Histology

    • architecture
      • tubulo-cystic: contains eosinophilic or basophilic secretions
      • papillary: small papillae, fibrovascular core may be hyalinized
      • diffuse sheets
    • cytology
      • flat, cuboidal or columnar
      • moderate-severe atypia
      • clear or eosinophilic cytoplasm
      • brisk mitosis

  • Stains

    • positive: CK7, CK20, CEA, CA125, p53, high Ki67
    • negative: PSA, ER/PR

  • Ddx

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