Papillary carcinoma


Expand All | Collapse All

  • Clinical

    • most common thyroid malignancy (80%)
    • age 20-50, female predominance 4:1
    • tx: near total thyroidectomy

  • Cytology

    • nuclear grooves, pseudoinclusions
    • irregular nuclear membrane, nucleoli
    • crowding, overlapping
    • can have: psammoma bodies, squamous metaplasia, papillary structures

  • Variants

    • follicular
    • macrofollicular
    • oncocytic (Hurthle cells)
    • Warthin-like (lymphoid infiltrate)
    • clear cell
    • diffuse sclerosing (diffuse rather than nodule, abundant squamous metaplasia and psammoma bodies)
    • tall cell
    • columnar cell
    • solid
    • cribiform
    • fasciitis-like stroma

  • Stains

    • positive: CK, thyroglobulin, TTF1, PAX8

  • Molecular

    • RET/PTC, TRK, RAS, BRAF

  • Ddx

    		•