LCIS


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  • Histology

    • lobular cytology
      • eccentric pink cytoplasm
      • cytoplasmic bubbles
      • round nuclei
      • smooth contours
    • expanded acini in > 50% of lobule
    • subtypes
      • florid
      • pleomorphic
      • collagen spherulosis

  • Stains

    • E-cadherin negative (vs ductal positive)
    • ER/PR+, Her2-

  • Ddx

    • ALH
    • low-grade DCIS with cancerization of lobule
    • myoepithelial cell hyperplasia

  • Sign out

    • Lobular carcinoma in situ (LCIS)
    • no invasive component identified
    • no need to report margin distance
    • no need to get hormone status
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