ALH


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  • Histology

    • lobular cytology
      • eccentric pink cytoplasm
      • cytoplasmic bubbles
      • round nuclei
      • smooth contours
    • expanded acini in lobule, but < 50%
  • Stains

    • E-cadherin negative (vs ductal positive)
  • Ddx

    • LCIS
    • low-grade DCIS with cancerization of lobule
    • myoepithelial cell hyperplasia