Grave disease


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  • Names

    • Grave disease
    • diffuse toxic goiter

  • Clinical

    • female predominance (5:1)
    • hyperthyroidism, low TSH

  • Gross

    • beefy red cut surface

  • Histology

    • small follicles
    • decreased colloid
    • scalloping
    • lymphocytic inflammation, patchy, stromal
    • nuclear atypia if radioactive iodine

  • Ddx

  • Associations

    • HLADR3
    • HLAB8
    		•