Follicular carcinoma


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  • Clinical

    • 5% of thyroid cancer
    • more prevalent in thyroid deficient areas
    • presents with cold nodule
    • euthyroid

  • Histology

    • full-thickness capsule invasion
    • LVSI
    • architecture
      • solid
      • trabecular
      • microfollicular
      • macrofollicular
    • uniform cytology

  • Ddx

    • follicular adenoma
      • no capsule invasion
      • no LVSI
    • atypical adenoma
      • partial capsule invasion
      • no LVSI
    • nodular hyperplasia
    • follicular variant of papillary carcinoma
      • papillary carcinoma nuclear features
    • follicular variant of medullary carcinoma
      • calcitonin+

  • Associations

    • t(2;3) PAX8/PPARgamma
    • Ras
    		•