AIS


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  • Clinical

    • 1 AIS per 36 cases of HSIL
    • management
      • colposcopy with endocervix sampling
      • diagnostic excision

  • Criteria

    • architecture
      • loss of honeycomb structure
      • sheets
      • clusters
      • pseudostratified strips
      • rosettes
    • nuclear atypia
      • NC ratio increased
      • crowding
      • overlap
      • pseudostratification
      • hyperchromasia
      • even coarse chromatin
      • nucleoli is usually inconspicuous
      • mitosis, apoptosis common
    • glandular features
      • columnar cells
      • featuring
      • elongated nuclei
      • feathering
      • strips, rosettes
    • no tumor diathesis

  • Ddx

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