adenocarcinoma


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  • Criteria

    • endocervical adenocarcinoma
      • architecture
        • sheets
        • clusters
        • syncytial
        • single
      • nuclear atypia
        • enlarged
        • pleomorphic
        • irregular chromatin
        • irregular membrane
        • macronucleoli
      • finely vacuolated cytoplasm
      • tumor diathesis common
    • endometrial adenocarcinoma
      • architecture
        • single
        • small tight clusters
      • nuclear atypia
        • enlarged
        • hyperchromasia
        • size variation
        • irregular chromatin
        • polarity loss
        • nucleoli
      • cytplasmic
        • scant cytoplasm
        • vacuoles
        • intracytoplasmic PMNs

  • Extrauterine types

    • vaginal
      • DES exposure in utero
    • ovarian
      • psammoma bodies
    • tubal
      • psammoma bodies
    • metastatic

  • Ddx

    • IUD
      • virtually indistinguishable from adenocarcinoma
    • reactive
      • IUD
      • prolapse
      • pessary
    • AIS
    • SCC
    • endocervical polyp atypia
      • enlarged vacuolated cells with engulfed PMNs
    • pemphigus vulgaris
    		•