undifferentiated carcinoma


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  • Synonyms

    • undifferentiated carcinoma
    • anaplastic carcinoma

  • Clinical

    • age 30+, median is 60s
    • male > female (2-3:1)
    • location: nasal cavity, maxillary antrum, ethmoid sinus
    • some cases s/p radiation for nasopharyngeal carcinoma
    • poor prognosis

  • Histology

    • lack squamous or glandular differentiation
    • high grade cytology
    • mitosis
    • necrosis
    • apoptosis
    • LVSI

  • Stains

    • panCK+
    • CK4, CK5/6, CK14 negative
    • rarely expresses neuro markers
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