tubular carcinoma


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  • Clinical

    • better prognosis
    • usually < 1.5 cm

  • Histology

    • glands: single layer tubular (mixed angulated/round) in > 90% of tumor, empty lumen (vs microglandular adenosis)
    • cytology: low grade. +/- snouts.
    • carcinoma features: infiltrative, desmoplasia
    • exclusion criteria: multilayering, pleomorphism, high mitosis

  • Stains

    • loss of myoeps (vs sclerosing adenosis)
    • almost always ER+, PR+
    • HER2-, p53-, Ki67 low

  • Ddx

    • Benign ddx: sclerosing adenosis (retains myoeps), microglandular adenosis (lobular, lumen secretions, S100+)
    • Malignant ddx: LG ductal carcinoma, tubulo-lobular carcinoma (glands rounder, has lobular component)
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