tuberculosis


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  • Histology

    • caseating necrosis
    • granulomas

  • Stains

    • AFB stains bacilli

  • Ddx

    • sarcoidosis
      • necrosis is rare and only focal
      • granulomas more uniform, well-formed
    • fungus
      • GMS stains hyphae
    • foreign body
      • non-necrotizing
      • polarizable foreign bodies
    • Kikuchi disease
      • coagulative (not caseating) necrosis
      • no well-formed granulomas or giant cells
    • Aggressive Bcell lymphoma
      • can have necrosis
      • sheets of atypical lymphoid cells
    • Hodgkin lymphoma
      • can have necrosis and granulomas
      • RS cells
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