thymus



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  • Normal

    • capsule
    • cortex
    • medulla
    • Hassall corpuscles
  • Non-neoplastic

  • WHO neoplasms

    • thymoma
    • thymic carcinoma
      • SCC
      • basaloid carcinoma
      • mucoepidermoid carcinoma
      • lymphoepithelioma like carcinoma
      • sarcomatoid carcinoma
      • clear cell carcinoma
      • adenocarcinoma
      • papillary adenocarcinoma
      • carcinoma with t(15;19) translocation
      • undifferentiated carcinoma
      • mixed
    • neuroendocrine
    • GCT
    • hematolymphoid
      • lymphoma
        • Hodgkin lymphoma
        • B cell lymphoma
        • T cell lymphoma
        • histiocytic and dendritic
          • langerhans cell histiocytosis
          • langerhans cell sarcoma
          • histiocytic sarcoma
          • malignant histiocytosis
          • follicular dendritic cell tumor
          • follicular dendritic cell sarcoma
          • interdigitating dendritic cell tumor
          • interdigitating dendritic cell sarcoma
        • myeloid sarcoma
        • AML
    • mesenchymal
      • thymolipoma
      • lipoma
      • liposarcoma
      • solitary fibrous tumor
      • synovial sarcoma
      • vascular neoplasms
      • rhabdomyosarcoma
      • leiomyomatous tumors
      • peripheral nerve tumors
    • rare mediastinal tumors
      • ectopic thyroid tumor
      • ectopic parathyroid tumor
    • metastasis
  • Type and grade

    • A: spindle cell thymoma
    • AB: mixed thymoma
    • B1: lymphocytic thymoma
    • B2: polygonal cell thymoma
    • B3: squamoid thymoma
    • C: thymic carcinoma
      • low grade
        • basaloid carcinoma
        • mucoepidermoid carcinoma
        • well-differentiated SCC
      • high grade
  • TNM (useful for grossing)

    • thymic epithelial tumors
      • T1: encapsulated
      • T2: pericapsular invasion
      • T3: neighbor invasion
        • pericardium
        • mediastinal pleura
        • thoracic wall
        • great vessels
        • lung
      • T4: pleura or pericardial dissemination
      • N1: anterior mediastinal nodes
      • N2: other intrathoracic nodes
      • N3: scalene or supraclavicular nodes
    • thymic GCT
      • T1: thymus confined
        • T1a: <= 5cm
        • T1b: > 5cm
      • T2: infiltrates contiguous organs or malignant effusion
        • T2a: <= 5cm
        • T2b: > 5cm
      • T3: neighbor invasion
        • pericardium
        • mediastinal pleura
        • thoracic wall
        • great vessels
        • lung
      • T4: pleural or pericardial dissemination
      • N1: regional node
      • N2: other intrathoracic nodes excluding anterior mediastinal
      • N3: scalene or supraclavicular
  • Staging

    • thymic epithelial tumors
      • I: T1
      • IIa: T2, microscopic
      • IIb: T2, macroscopic
      • III: T3
      • IVa: T4
      • IVb: N1, LVSI or M1
    • thymic GCT
      • I: complete resection
      • II: microscopic residual tumor
      • III: gross residual tumor
      • IV: metastasis