thrombocytopenia



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  • Destruction/consumption

    • destruction (immunologic)
      • ITP
      • HIT
      • autoimmune/autoantibodies
      • alloantibodies: maternal, against donor plt
    • MAHA
      • TTP
      • HUS
      • DIC
    • mechanical shear: malig HTN, HELLP, valves
  • Abnormal distribution

    • splenomegaly
    • hypothermia: pooling in spleen
    • dilution from transfusion
    • pregnancy: plt > 70
  • Infection

    • infection -> megakaryocyte apoptosis
    • screen for HIV, HCV
  • Decreased megas

    • aplastic anemia
      • Fanconi anemia
      • PNH
    • (a)megakaryocytic anemia
    • injury: chemorad, infection
  • Adequate mega number, but ineffective

  • Artifact: clumping, giant plt