spermatocytic seminoma


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  • Clinical

    • average age 52
    • negative serum markers

  • Histology

    • noncohesive
    • 3 cell types: small cells with dark nuclei, medium spermatocyte-like, and giant mononuclear cells
    • stroma: edematous or scant
    • lack in situ component

  • Stains

    • VASA+
    • focal PLAP

  • Ddx

    • seminoma
      • fibrous stroma
      • lymphocytic infiltrate
      • PLAP diffusely positive
      • has in situ component
    • lymphoma
    		•