sertoli cell tumor


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  • Names

    • Sertoli cell tumor
    • androblastoma

  • Clinical

    • testicular
      • children (syndrome associated), adults around 45
      • syndromes: androgen insensitivity, Carney syndrome, Peutz Jeghers

  • Histology

    • architecture: tubules, sheets, cords, nests
    • cytology: bland, uniform, can have mild atypia
    • stroma: fibrotic
    • malignant features
      • more sheet pattern
      • nuclear pleomorphism, nucleoli
      • numerous mitosis
      • necrosis
      • LVSI

  • Variants

    • LCCSCT
    • sclerosing sertoli cell tumor

  • Stains

    • vimentin, CK+
    • negative PLAP, AFP, hCG
    • variable inhibin, S100

  • Ddx

    • sertoli cell nodule
    		•