seminoma


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  • Clinical

    • testicular
      • painless testicular enlargement/mass
      • hypoechoic mass

  • Histology

    • sheets, clusters, columns
    • cytology: uniform, round/polygonal, clear cytoplasm
    • lymphocytic infiltrate
    • microinvasion = interstitial invasion only
    • can have syncytiotrophoblastic cells

  • Stains

    • PLAP, CD117+

  • Ddx

    • embryonal carcinoma
      • CD117-
      • CD30+
      • diffuse CK
    • choriocarcinoma
      • have cytotrophoblasts
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