pleomorphic liposarcoma


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  • Clinical

    • rarest (5%) liposarcoma
    • age > 50
    • site: extremities
    • aggressive, 30-50% metastasis, 40-50% mortality

  • Histology

    • pleomorphic lipoblasts
    • stroma: spindle, round, and multinucleated giant cells

  • Stains

    • vimentin+
    • S100 +/-
    • can have focal CK+

  • Molecular

    • MDM2 +/-
    • TP53 +/-

  • Ddx

    		•