Apps
Surgpath
→
MSK
→
soft tissue
dedifferentiated liposarcoma
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Clinical
site: retroperitoneum (most common), extremities, spermatic cord, head/neck, trunk
Histology
high grade stromal cells
heterologous elements in 5-10%
Molecular
MDM2 amplification in retroperitoneal
TP53 in non-retroperitoneals
Ddx
well differentiated liposarcoma
MFH