pancreas




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  • Normal

    • exocrine
      • acini
        • single layer
        • triangular cells
        • apical pink granules
        • no myoeps
        • can have central acinar cell (beginning of duct)
      • ducts
        • main pancreatic duct
          • simple columnar mucinous
          • round basal nuclei
          • thick collagen around it
        • interlobular duct
          • low columnar mucinous
          • basal nuclei
          • thick collagen around it
        • intercalated duct
          • cuboidal epithelium without mucin
          • round nuclei
          • minimal connective tissue
    • endocrine
      • islet of langerhans
        • compact type: most common, balls of cells
        • diffuse type: inferior head of pancreas, looks like scar
    • connective tissue, intrapancreatic fat
    • focal acinar transformation

  • Non-neoplastic

  • WHO neoplasms

  • TNM (useful for grossing)

    • Tis: in situ
    • T1: 2 cm or less
    • T2: > 2 cm
    • T3: extension beyond pancreas (into duodenum, bile duct, peripancreatic tissue)
    • T4: involves celiac axis or SMA

  • Staging

    • 0: Tis
    • IA: T1
    • IB: T2
    • IIA: T3
    • IIB: N1
    • III: T4
    • IV: M1
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