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Normal
cortex
epithelium
simple columnar
follicles
corpus luteum
mature corpus luteum: pink granulosa-lutein cells
degenerating corpus luteum: white granulosa-lutein cells filled with lipid
corpus albicans
corpus luteum of pregnancy
stroma
plump spindle cells
luteinized cells
polygonal, eosinophilic to clear cytoplasm, round central nucleus with prominent nucleoli
medulla
stroma: same as cortex stroma
blood vessels
hilus
rete ovarii
leydig-like cells
Non-neoplastic
Cysts
Corpus luteum cyst
prominent connective tissue
follicular cyst
granulosa cell inner lining
theca cell outer lining
epidermal inclusion cyst
statified squamous lining with granular layer
Filled laminated keratin
vs trichilemmal cyst: no granular layer, compact wet keratin)
peritoneal inclusion cyst
Walthard nest
endosalpingiosis
PCOD
multiple cortical cysts
PCOS
hyperreactio luteinalis
endometriosis
Walthard nest
Inflammation
infection
tuboovarian abscess
PID
xanthogranuloma
malakoplakia
other bacterial, fungal and viral
granulomatous oophoritis
foreign body granuloma
necrobiotic granuloma
sarcoidosis
Crohns disease
cortical granuloma
Hyperplasia
stromal hyperplasia and hyperthecosis
granulosa cell prolif of pregnancy
hilar leydig cell hyperplasia
Metaplasia
decidua
smooth muscle metaplasia
Heterotopia
endometriosis
nests of endometrial stromal cells
leydig cells
Reinke crystals
neuroendocrine cells
spleen
prostate
adrenal rest
Others
luteoma of pregnancy
cortical granuloma
hyaline scar
papillary stromal projections
serous surface papilloma
mesothelial cell hyperplasia
response to PID
can be florid tubulopapillary, pseudoinfiltrative, nuclear atypia
ddx mesothelioma
epithelial tumors
germ cell tumors
sex cord stromal tumors
Other neoplasms
Mixed GCT-SCT
gonadoblastoma
mixed germ cell - sex cord stromal tumor
rete ovarii
adenocarcinoma
adenoma
cystadenoma
cystadenofibroma
dermoid cyst-associated
carcinoma
SCC
adenocarcinoma
sebaceous
sebaceous adenoma
sebaceous carcinoma
sarcoma
melanocytic
melanoma
nevus
misc tumors
neuroendocrine
small cell carcinoma
large cell neuroendocrine carcinoma
hepatoid carcinoma
mesothelioma
Wilms tumor
GTDs
gestational choriocarcinoma
hydatidiform mole
adenoid cystic carcinoma
basal cell tumor
ovarian wolffian tumor
paraganglioma
myxoma
soft tissue
tumor-like conditions
luteoma of pregnancy
stromal hyperthecosis
stromal hyperplasia
fibromatosis
massive ovarian edema
hematolymphoid
lymphoma
plasmacytoma
peritoneal
serous adenocarcinoma
borderline tumor
mesothelioma
adenomatoid tumor
leiomyomatosis
desmoplastic small round cell tumor
TNM (useful for grossing)
T1: limited to ovary(s)
T1a: unilateral
T1b: bilateral
T1c: tumor ruptured, on surface, or in peritoneal fluid
T2: pelvic involvement
T2a: uterus or tube involvement
T2b: other pelvic tissue involvement
T2c: malignant peritoneal fluid
T3: peritoneal involvement or N1
T3a: microscopic only
T3b: <= 2cm
T3c: > 2cm or N1
Staging
I: T1
IA: T1a
IB: T1b
IC: T1c
II: T2
IIA: T2a
IIB: T2b
IIC: T2c
III: T3 or N1
IIIA: T3a
IIIB: T3b
IIIC: T3c or N1
IV: M1