medulloblastoma


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  • Clinical

    • 4th ventricle, cerebellum

  • Histology

    • classic small round blue cells or anaplastic type
    • densely packed

  • Types

    • classic (nodules, no desmoplasia)
    • desmoplastic/nodular (nodules, reticulin septa)
    • extensive nodularity (nodules >> reticulin septa)
    • large cell anaplastic
    • WNT activated
    • SHH activated: +/- p53 mutation
    • non WNT/SHH

  • Stains

    • variable: NSE, synaptophysin
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