medullary carcinoma


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  • Entities

    • carcinoma with medullary features (umbrella term)
    • medullary carcinoma (classic histology)
    • atypical medullary carcinoma (lacks some features)
    • ductal carcinoma with medullary features (lacks some features)

  • Histology

    • well circumscribed or pushing margins
    • syncythial architecture in > 75%, lack tubule formation
    • high grade cytology, numerous mitosis, frequent necrosis
    • diffuse lymphoplasmacytic stromal infiltrate
    • can have...
      • atypical giant cells
      • cystic degeneration

  • Stains

    • usually triple negative (ER/PR/Her2)
    • variably positive: CK5/6, p53
    • typically EBV-

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    • carcinoma with medullary features, see comment
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