low grade serous carcinoma


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  • Histology

    • Architecture
      • invasion
      • single cells, nests, or less commonly papillae
    • cytology: mild-moderate atypia
    • lacks necrosis
    • low mitosis (less than 2-3 per 10HPF)
    • psammoma bodies

  • Stains

    • positive: AE1AE3, EMA, BerEP4, WT1, PAX8, ER, PR (can be lower in 50%)
    • negative for diffuse p16 or mutated p53

  • Molecular

    • KRAS, BRAF in 50%

  • Ddx

    • borderline tumors: no invasion
    • high grade serous carcinoma: overt pleomorphism, necrosis, mitosis
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