hemochromatosis


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  • Clinical

    • hereditary hemochromatosis (autosomal recessive)
    • juvenile hemochromatosis (autosomal dominant)
    • chronic transfusion
    • hemolytic anemia

  • Gross

    • rusty color
    • nodular (cirrhosis)

  • Histology

    • iron deposition
      • hereditary hemochromatosis: hepatocyte iron, predominantly periportal
      • secondary iron overload: Kupffer cell iron (lines sinusoids)
      • oral iron: portal iron
    • cirrhosis

  • Molecular

    • hereditary hemochromatosis: HFE mutation
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