gonadoblastoma


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  • Clinical

    • testicular: mixed gonadal dysgenesis with ambiguous genitalia

  • Histology

    • nested nodules
    • germ cells
    • immature sertoli cells
    • 50% develop GCTs (mainly seminoma)

  • Stains

    • germ cells express VASA, TSPY, p53, PLAP, ckit
    • stromal cells express inhibin, WT1
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