gliomatosis cerebri


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  • Clinical

    • involves large regions of CNS
    • multiple lobes or bilateral hemispheres

  • Histology

    • mostly astrocytic, can be oligo
    • atypical spindle cells, infiltrative
    • advanced disease may have necrosis and vascular proliferation

  • Stains

    • variable GFAP and S100
    • Ki67 < 30%
    		•