epithelioid hemangioendothelioma


Expand All | Collapse All

  • Clinical

    • site: extremities
    • prognosis: between hemangioma and angiosarcoma

  • Histology

    • most originate from a vessel, usually small vein, showing intraluminal growth
    • cytology: round to slightly spindle pink endothelial cells, cytoplasmic vacuoles containing RBCs
    • can have metaplastic bone with oscteoclastic giant cells
    • malignant features: nucleat atypia, mitosis > 1 per 10 hpf, spindle cells, necrosis

  • Stains

    • positive: CD31, CD34
    • 25% have focal CK

  • Ddx

    		•