ductal carcinoma


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  • Other names

    • carcinoma of no special type

  • Variants

    • pleomorphic carcinoma
    • carcinoma with osteoclast like stroma giant cells
    • carcinoma with choriocarcinomatous features
    • carcinoma with melanotic features

  • Stains

    • cytokeratin+
    • E-cadherin+ (vs lobular negative)
    • myoepithelial markers negative (vs DCIS positive)
      • p63
      • smooth muscle myosin
    • low grade ductal carcinoma is Her2 negative

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    • Invasive ductal carcinoma
    • Nottingham combined histologic grade: *** of 3
      • Tubule formation score: *** of 3
      • Nuclear pleomorphism score: *** of 3
      • Mitotic count score: *** of 3
    • Carcinoma measures *** in greatest linear extent
    • Look for associated DCIS (extensive intraductal component if > 25% of tumor)
    • Comment on calcifications
    • Get ER, PR, Her2
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