diffuse astrocytoma


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  • Clinical

    • adults
    • site: frontotemporal lobes, brain stem, spinal cord
    • 10-15% of all astrocytic tumors
    • WHO grade II

  • Histology

    • moderate hypercellularity
    • atypical astrocytes, loose/microcystic stroma
    • minimal mitosis
    • lack necrosis or microvascular proliferation
    • Variants
      • fibrillary astrocytoma
      • gemistocytic astrocytoma
        • > 20% gemistocytes
        • perivascular lymphocytes
      • protoplasmic astrocytoma
        • rare
        • extensive mucin microcysts
        • low GFAP

  • Stains

    • GFAP+
    • Ki67 < 5%
    		•