cribriform carcinoma


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  • Clinical

    • better prognosis

  • Histology

    • Cribriform in > 90% (exception is can have up to 50% tubular carcinoma component)
    • invasive (vs DCIS), desmoplasia, +/- DCIS
    • Cytology: can have some pleomorphism, but mitosis rare

  • Stains

    • loss of myoeps
    • ER+, PR+/-

  • Ddx

    • DCIS (retains myoeps)
    • Adenoid cystic ca (CD117)
    • Neuroendocrine (synaptophysin)
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