Intrinsic (aPTT)

• 8: hemophilia A, classic hemophilia
• 9: hemophilia B, xmas disease
• 11, 12
• associated: PK (prekallikrein), HMWK (high molecular weight kininogen)
• antiphospholipid syndrome

Extrinsic (PT)

• 7
• PT test (note: contains heparinase)
• INR = PT patient / PT normal

Common (both)

• 1 fibrinogen: low in DIC
• (2)a (pro)thrombin: argatroban, dabigatran
• 5
• 10: heparin, -Xaban, fondaparinux
• associated: phospholipids
• TT (thrombin time) measures thrombin + fibrinogen -> fibrin

Other factors

• 13 (crosslinks fibrin)
• thrombomodulin
• plasmin(ogen) degrades fibrin

VWD

platelet disease

Warfarin

• inhibits vitamin K
• VitK factors: 2, 7, 9, 10, protein C, S, Z
• Bridge with heparin bcz protein C & S drops first

Factor bleeding threshold

• 50-100 mg/dL fibrinogen
• 20-30% prothrombin
• 15-20%: 5, 7, 10, 11, combined 5+8, combined VitK
• 2-5%: 13