benign serous tumor


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  • Types

    • serous cystadenoma
    • serous cystadenofibroma
    • serous surface papilloma
    • benign serous tumor with focal epithelial proliferation

  • Histology

    • architecture
      • simple branching of papilla
      • cyst: cystadenoma, cystadenofibroma
      • surface exophytic lesion: surface papilloma
      • focal epithelial proliferation = hierarchical branching in < 10% epithelial volume (comment on cystic vs surface involvement)
    • lining: cilia, sometimes flat nondescript lining
    • stroma: adenofibroma if has fibrous tissue

  • Ddx

    • Cortical inclusion cyst: size < 1 cm
    • Peritoneal inclusion cyst: mesothelial lining
    • benign serous tumor with focal epithelial proliferation: borderline component < 10% in epithelial volume
    • serous borderline tumor: complex branching architecture

  • Molecular

    • lacks KRAS or BRAF mutations (vs borderline tumor)
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