anaplastic carcinoma
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Clinical- age 60-70s
- lymph node mets likely
- life expectancy 6 months
- arises from preexisting carcinoma, usually papillary
Histology- patterns
- squamoid
- spindle cell
- giant cell
- preexisting papillary carcinoma
Stains- thyroglobulin, TTF1 -/+
- CK, EMA patchy
- vimentin+
Ddx- lymphoma
- metastasis
- papillary carcinoma, solid variant
- thyroglobulin stronger positivity
- sarcoma
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