adult granulosa cell tumor


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  • Clinical

    • elevated inhibin and mullerian-inhibiting hormone
    • testicular
      • 25% have gynecomastia
      • average age 44

  • Histology

    • patterns: microfollicular (most common), macrofollicular, insular, trabecular, gyriform, solid, pseudosarcomatous
    • Call-Exner bodies
    • cytology: round/oval, coffee-bean nuclei, peripheral nucleoli
    • may have focal theca cell, smooth muscle or osteoid

  • Stains

    • vimentin, SMA, inhibin+
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