Hurthle cell neoplasm

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  • Clinical

    • 30% has nodal metastasis (vs regular follicular neoplasm)
    • carcinoma vs adenoma depends on capsule invasion
    • lobectomy, followed by completion thyroidectomy if carcinoma
  • Cytology

    • follicular, trabecular or solid, crowded or dyscohesive
    • abundant granular cytoplasm, can have prominent clear cell change
    • prominent nucleoli
    • can have psammoma-like colloid bodies
  • Stains

    • TTF1
  • Ddx

  • Signout

    • suspicious for follicular neoplasm, Hurthle cell type