Benign follicular nodule


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  • Entities

    • multinodular goiter (clinical diagnosis)
    • adenomatoid nodule (macrofollicles)
    • colloid nodule (entirely colloid)
    • follicular adenoma macrofollicular variant

  • Cytology

    • predominantly orderly macrofollicles
    • macrofollicle = evenly spaced cells (no crowding or overlap)
    • small component of microfollicles and trabecula

  • Ddx

    • follicular carcinoma
      • lots of microfollicles, crowded trabecula
    • papillary carcinoma
      • nuclear pseudoinclusions
      • fragmented follicles and macrophage aggregates can mimick papillary carcinoma
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