Hashimoto disease


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  • Names

    • Hashimoto disease
    • chronic lymphocytic thyroiditis

  • Clinical

    • female (5:1 predominance)
    • hypothyroid, high TSH

  • Histology

    • germinal centers
    • lymphoplasmacytic
    • oncocytic metaplasia
    • fibrosis in late stage

  • Stains

    • mixed B/T cells
    • polyclonal plasma cells

  • Ddx

    • lymphoma
    • nonspecific lymphocytic thyroiditis

  • Associations

    • increased risk for thyroid lymphoma
    • slight increase incidence of papillary carcinoma
    • HLADR3, HLADR5
    • Turner, Down, Alzheimer
    • autoimmune diseases
    • IgG4
    		•