HSV


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  • Clinical

    • tender lymphadenopathy

  • Histology

    • paracortical hyperplasia with immunoblasts
    • necrosis with PMNs, but no granuloma
    • viral inclusions (multiple moulded nuclei), esp in necrotic zones

  • Stains

    • HSV+

  • Ddx

    • Kikuchi disease
      • CD123+ plasmacytoid dendritic cells
      • lack PMNs, viral inclusions
    • Cat scratch disease
      • Warthin-Starry stains microorganisms
      • little necrosis, can have granuloma
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