GIST
      
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Clinical- age: 50-60. Young in Carney triad.
- location: stomach, intestines
- also omentum, peritoneum, retroperitoneum
- rarely esophagus
- can be benign or malignant
- intestinal GIST more likely malignant
- associations: NF1, familial GIST (ckit, PDGFRA mutation), Carney triad (gastric GIST, paraganglioma, pulmonary chondroma)
Histology- sheets, fascicles, whirls, palisades
- spindle and epithelioid cells
- may have perinuclear vacuoles
- features of malignancy
- size > 10 cm
- mitosis >= 1 per 10 hpf
- for stomach, both criteria makes it malignant
- for intestine, any criteria makes it malignant
StainsMolecularDdx
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