Burkitt lymphoma


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  • Clinical Variants

    • Endemic
      • Equatorial Africa
      • children
      • male predominance (2:1)
      • 100% EBV
      • site: mostly jaw and face
    • Sporadic
      • children and young adult
      • male predominance (2-3:1)
      • 30% EBV
      • site: mostly abdominal
    • Immunocompromised
      • HIV
      • 25-40% EBV
      • site: nodal, marrow involvement

  • Morphology

    • starry sky (macrophages ingesting apoptotic cells)
    • mitosis
    • can have granulomatous inflammation
    • can have plasmacytoid differentiation, esp in immunocompromised

  • Stains

    • positive: B markers, CD10, BCL6, CD38, CD77, CD43, Ki67 (>95%)
    • negative: BCL2, TdT

  • Molecular

    • MYC translocation, 8q24
    • usually with IGH, t(8;14)
    • other myc txl: t(8;22), t(2;8)
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