HIV


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  • Clinical

    • 60-200x risk of getting non-Hodgkin lymphoma
    • sites: nodes, GI, CNS, liver, marrow, other extranodal sites
    • EBV association: Hodgkin, CNS lymphoma, primary effusion lymphoma, DLBCL with immunoblastic features, Burkitt
    • HHV8 association: primary effusion lymphoma

  • Types

    • Burkitt (30%)
      • early HIV infection with CD4 > 200 E6
      • EBV+ in 30%
      • plasmacytoid differentiation in 2/3
    • DLBCL (25-30%)
      • late AIDS with CD4 < 100 E6
      • EBV+ in 30%
    • DLBCL immunoblastic variant
      • has 90% immunoblasts
      • plasmacytoid features
      • EBV+ in 90%
      • primary CNS lymphoma usually this variant
    • Hodgkin
      • usually mixed cellularity or lymphocyte depleted forms
      • almost always EBV+
      • risk is paradoxically lower in more severe immunocompromise
    • HIV-specific
    • PTLD-like proliferation
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