Anaplastic carcinoma


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  • Clinical

    • age 60-70s
    • lymph node mets likely
    • life expectancy 6 months
    • arises from preexisting carcinoma, usually papillary

  • Histology

    • patterns
      • squamoid
        • usually nonkeratinizing
      • spindle cell
      • giant cell
    • preexisting papillary carcinoma

  • Stains

    • thyroglobulin, TTF1 -/+
    • CK, EMA patchy
    • vimentin+

  • Ddx

    • lymphoma
    • metastasis
    • papillary carcinoma, solid variant
      • thyroglobulin stronger positivity
    • sarcoma
      • CK-
    		•