ASCH


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  • Clinical

    • 0.3% of all paps
    • prognosis
      • 50% risk for HSIL
    • management
      • colposcopy

  • Criteria

    • small cells with high NC ratio
      • single or small groups < 10 cells
        • may stream in mucus
      • cell size = metaplastic squams
      • nuclei 1.5-2.5x normal
      • NC ratio high, ~ HSIL
      • other nuclear atypia
        • nuclear irregularity
        • hyperchromasia
        • chromatin irregularity
    • crowded sheet
      • crowded squams
      • nuclear atypia

  • In practice

    • HSIL, but not enough cells
    • small cells with high NC ratio
    • crowded sheets with nuclear atypia
    • atypical squamous metaplasia
      • small cells
      • mild-moderate nuclear atypia

  • Ddx

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