transient abnormal myelopoiesis


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  • Clinical

    • 10% of DS newborns
    • thrombocytopenia
    • spontaneous remission in first 3 months
    • 30% develop AML 1-3 years later

  • Morphology

    • just like AML
    • megakaryocytic features

  • Immunophenotype

    • positive: CD34, CD56, CD117, CD41, CD42, CD61
    • negative: MPO, CD15, CD14, glycophorin A

  • Molecular

    • trisomy 21
    • GATA1 mutation
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