thrombotic microangiopathy


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  • Names

    • malignant nephrosclerosis
    • thrombotic microangiopathy

  • Clinical

    • malignant hypertension
    • TTP, HUS
    • DIC

  • Gross

    • petechial subcapsular hemorrhage
    • red-yellow mottling if infarct
    • normal weight

  • Histology

    • acute: fibrinoid necrosis (arterioles and glomeruli)
    • chronic: glomerular collapse, glomerular basement membrane duplication, proliferative endarteritis (concentric/onion skin myointimal proliferation in artery)
    • other findings: RBC in tubules, thrombi in vessels and glomeruli, fragmented RBCs
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