tenosynovial giant cell tumor


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  • Names

    • tenosynovial giant cell tumor
    • giant cell tumor of tendon sheath
    • nodular tenosynovitis

  • Clinical

    • age: 30-50
    • site: predominantly hand. Also, wrist, foot/ankle, knee. Rarely elbow, hip.

  • Histology

    • well circumscribed
    • multinucleated giant cells
    • hemosiderin pigment virtually always present
    • mononuclear cells
    • foamy macrophages
    • mitosis 3-5 per 10 hpf, but can be higher
    • can have rare, focal necrosis

  • Stains

    • multinucleated giant cells: CD68, CD45, TRAP
    • mononuclear cells: CD68, CD163, CD45

  • Molecular

    • t(X;18) = SS18-SSX fusion
    • in almost all
    		•