systemic T cell lymphoproliferative disease of childhood


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  • Names

    • systemic EBV positive T cell lymphoproliferative disease of childhood

  • Clinical

    • EBV infection, acute or chronic
    • children and young adults
    • Asian prevalence
    • infectious sx, organomegaly
    • pancytopenia

  • Morphology

    • T cells infiltrating sinusoids (liver, spleen), around follicles (nodes)
    • hemophagocytosis

  • Stains

    • positive: CD2, CD3, TIA1, EBV
    • negative: CD56
    • CD8+ (acute), CD4+ (chronic), rare coexpression
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